New project realised by Karolina Cysewska's team, financed by NCRD (NCBR) | Faculty of Electronics, Telecommunications and Informatics at the Gdańsk University of Technology

The project “Innovative stent coating with polyphenol-rapamycin complex with improved drug-eluting properties to target in-stent restenosis (PoRaCoat)”, financed by the National Center for Research and Development in the amount of 1 423 392,88 PLN from the M-ERA.NET 3 Call 2023 competition, aims to develop an innovative drug release system based on a conductive polymer matrix for commercial cobalt-chromium stents. The project, except Gdańsk University of Technology, involves 3 foreign partners and one company:

1. Balton Sp. z o.o., Poland
2. Fraunhofer IKTS, Germany (Coordinator)
3. University Hospital Dresden, Department of Visceral-, Thoracic and Vascular Surgery, Division of Vascular and Endovascular Surgery (UKD), Germany
4. National University of Science and Technology Politehnica Bucharest, Romania.

The expected key results of the project will be a prototype of a stent coating based on a conductive polymer matrix PEDOT with an incorporated polyphenol complex and an antiproliferative drug; a system for coating Co-Cr substrates with these coatings by the electrodeposition method will be developed; adding the developed drug complex to the polymer matrix will allow for more effective and safer drug release compared to commercially available solutions. The developed coating prototype will allow for a controlled degradation rate, continuous and uniform drug release in optimal concentrations, appropriate hemo- and cytocompatibility, supporting endothelial adhesion while limiting smooth muscle adhesion.
PI of project in PL: dr inż. Karolina Cysewska.

Project is financed for 36 months and will be realised in dates: 01.06.2024-31.05.2027.